Malcolm A. Leissring: search on Z-Library

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1

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

Mark P Mattson, Frank M LaFerla, Sic L Chan, Malcolm A Leissring, P.Nickolas Shepel, Jonathan D Geiger

Journal:

Trends in Neurosciences

Year:

2000

Language:

english

File:

PDF, 696 KB

english, 2000

2

Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice

Malcolm A. Leissring, Yama Akbari, Christopher M. Fanger, Michael D. Cahalan, Mark P. Mattson and Frank M. LaFerla

Journal:

The Journal of Cell Biology

Year:

2000

Language:

english

File:

PDF, 1.32 MB

english, 2000

3

Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro

Hogan, Meghan F., Meier, Daniel T., Zraika, Sakeneh, Templin, Andrew T., Mellati, Mahnaz, Hull, Rebecca L., Leissring, Malcolm A., Kahn, Steven E.

Journal:

Year:

2016

Language:

english

File:

PDF, 169 KB

english, 2016

4

Loss of Neprilysin Function Promotes Amyloid Plaque Formation and Causes Cerebral Amyloid Angiopathy

Wesley Farris, Sonja G. Schütz, John R. Cirrito, Ganesh M. Shankar, Xiaoyan Sun, Ana George, Malcolm A. Leissring, Dominic M. Walsh, Wei Qiao Qiu, David M. Holtzman, Dennis J. Selkoe

Journal:

The American Journal of Pathology

Year:

2007

Language:

english

File:

PDF, 1.06 MB

english, 2007

5

Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

Villa-Pérez, Pablo, Merino, Beatriz, Fernández-Díaz, Cristina M., Cidad, Pilar, Lobatón, Carmen D., Moreno, Alfredo, Muturi, Harrison T., Ghadieh, Hilda E., Najjar, Sonia M., Leissring, Malcolm A., Có

Journal:

Year:

2018

Language:

english

File:

PDF, 5.36 MB

english, 2018

6

Structural biology: Enzyme target to latch on to

Leissring, Malcolm A., Selkoe, Dennis J.

Journal:

Year:

2006

Language:

english

File:

PDF, 300 KB

english, 2006

7

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

Zeshan Ahmed, Hong Sheng, Ya-fei Xu, Wen-Lang Lin, Amy E. Innes, Jennifer Gass, Xin Yu, Harold Hou, Shuichi Chiba, Keitaro Yamanouchi, Malcolm Leissring, Leonard Petrucelli, Masugi Nishihara, Michael

Journal:

The American Journal of Pathology

Year:

2010

Language:

english

File:

PDF, 1.79 MB

english, 2010

8

Functional cDNA screening identifies BACE-2 as a principal beta-amyloid degrading protease

Samer Abdul-Hay, Malcolm Leissring, Tomoko Sahara, Melinda McBride, Dongcheul Kang

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 51 KB

english, 2011

9

Regulation of distinct pools of amyloid β-protein by multiple cellular proteases

Malcolm A Leissring,Anthony J Turner

Journal:

Alzheimer's Research & Therapy

Year:

2013

Language:

english

File:

PDF, 213 KB

english, 2013

10

Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease

Leissring, Malcolm A.

Journal:

Year:

2016

Language:

english

File:

PDF, 518 KB

english, 2016

11

Development and Characterization of Quantitative, High-Throughput-Compatible Assays for Proteolytic Degradation of Glucagon

Suire, Caitlin N., Lane, Shelley, Leissring, Malcolm A.

Journal:

Year:

2018

Language:

english

File:

PDF, 433 KB

english, 2018

12

Alzheimer's Presenilin-1 Mutation Potentiates Inositol 1,4,5-Trisphosphate-Mediated Calcium Signaling in Xenopus

Malcolm A. Leissring, Brooke A. Paul, Ian Parker, Carl W. Cotman, Frank M. LaFerla

Journal:

Journal of Neurochemistry

Year:

1999

Language:

english

File:

PDF, 166 KB

english, 1999

13

Proteolytic Degradation of the Amyloid β-Protein: The Forgotten Side of Alzheimers Disease

Leissring, Malcolm

Journal:

Current Alzheimer Research

Year:

2006

Language:

english

File:

PDF, 87 KB

english, 2006

14

Age and Its Association with Low Insulin and High Amyloid-β Peptides in Blood

Li, Huajie, Zhu, Haihao, Wallack, Max, Mwamburi, Mkaya, Abdul-Hay, Samer O., Leissring, Malcolm A., Qiu, Wei Qiao

Journal:

Journal of Alzheimer's Disease

Year:

2015

Language:

english

File:

PDF, 84 KB

english, 2015

15

Characterization of brain region- and disease-specific IDE expression in Alzheimer patients and controls

Richard J. Miles, Anthony DelleDonne, Fanggeng Zou, Melissa Murray, Li Ma, Thuy Nguyen, Gina Bisceglio, Dennis W. Dickson, Steven Younkin, Malcolm A. Leissring, Nilufer Ertekin-Taner

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

16

AÎ² degradationâ€”the inside story

Leissring, Malcolm A.

Journal:

Frontiers in Aging Neuroscience

Year:

2014

Language:

english

File:

PDF, 318 KB

english, 2014

17

Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme

Anthony DelleDonne, Naomi Kouri, Lael Reinstatler, Tomoko Sahara, Lilin Li, Ji Zhao, Dennis W Dickson, Nilufer Ertekin-Taner, Malcolm A Leissring

Journal:

Molecular Neurodegeneration

Year:

2009

Language:

english

File:

PDF, 800 KB

english, 2009

18

Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity

Abdul-Hay, Samer O., Lane, Amy L., Caulfield, Thomas R., Claussin, Clémence, Bertrand, Juliette, Masson, Amandine, Choudhry, Shakeel, Fauq, Abdul H., Maharvi, Guhlam M., Leissring, Malcolm A.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.63 MB

english, 2013

19

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

Ji Zhao, Lilin Li, Malcolm A Leissring

Journal:

Molecular Neurodegeneration

Year:

2009

Language:

english

File:

PDF, 341 KB

english, 2009

20

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life

Ganesh M. Shankar, Malcolm A. Leissring, Anthony Adame, Xiaoyan Sun, Edward Spooner, Eliezer Masliah, Dennis J. Selkoe, Cynthia A. Lemere, Dominic M. Walsh

Journal:

Neurobiology of Disease

Year:

2009

Language:

english

File:

PDF, 1.20 MB

english, 2009

21

Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display

Suire, Caitlin N., Nainar, Sarah, Fazio, Michael, Kreutzer, Adam G., Paymozd-Yazdi, Tara, Topper, Caitlyn L., Thompson, Caroline R., Leissring, Malcolm A., Baek, Kwang-Hyun

Journal:

Year:

2018

Language:

english

File:

PDF, 3.46 MB

english, 2018

22

Presenilin-1 Immunoreactivity Is Localized Intracellularly in Alzheimer's Disease Brain, but Not Detected in Amyloid Plaques

Libby L. Weber, Malcolm A. Leissring, Austin J. Yang, Charles G. Glabe, David H. Cribbs, Frank M. LaFerla

Journal:

Experimental Neurology

Year:

1997

Language:

english

File:

PDF, 464 KB

english, 1997

23

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

Leissring, Malcolm A., Malito, Enrico, Hedouin, Sabrine, Reinstatler, Lael, Sahara, Tomoko, Abdul-Hay, Samer O., Choudhry, Shakeel, Maharvi, Ghulam M., Fauq, Abdul H., Huzarska, Malwina, May, Philip S

Journal:

Year:

2010

Language:

english

File:

PDF, 2.18 MB

english, 2010

24

Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling

Malcolm A. Leissring, Frank M. LaFerla, Nick Callamaras, Ian Parker

Journal:

Neurobiology of Disease

Year:

2001

Language:

english

File:

PDF, 232 KB

english, 2001

25

10.1038/90249

Marchant, Jonathan S., Stutzmann, Grace E., Leissring, Malcolm A., LaFerla, Frank M., Parker, Ian

Journal:

Nature Biotechnology

Year:

2001

Language:

english

File:

PDF, 2.44 MB

english, 2001

26

Identification of secretase-independent beta-amyloid-lowering agents via ultra-high throughput compound screening

Leissring, Malcolm

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 51 KB

english, 2011

27

Cathepsin D knockout mice harbor large and highly selective increases in cerebral Aß42 and tau: Implications for Alzheimer's disease pathogenesis

Malcolm A. Leissring, Lael Reinstatler, Tomoko Sahara, Daniel Sevlever, Robert Roman, Zhao Ji, Lilin Li, Qun Lu, Paul Säftig, Yona Levites, Todd E. Golde, Jeremy Burgess, Nilufer Ertekin-Taner, Elizab

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 117 KB

english, 2009

28

Cathepsin D regulates cerebral AÎ²42/40 ratios via differential degradation of AÎ²42 and AÎ²40

Suire, Caitlin N., Abdul-Hay, Samer O., Sahara, Tomoko, Kang, Dongcheul, Brizuela, Monica K., Saftig, Paul, Dickson, Dennis W., Rosenberry, Terrone L., Leissring, Malcolm A.

Journal:

Alzheimer's Research & Therapy

Year:

2020

File:

PDF, 1.43 MB

2020

29

Association of a missense cathepsin D (CTSD) SNP with risk of Alzheimer's disease

Burgess, Jeremy, Leissring, Malcolm A., Ma, Li, Younkin, Linda H., Reinstatler, Lael, Crook, Julia E., Pankratz, V. Shane, Dickson, Dennis W., Peterson, Ronald C., Graff-Radford, Neill R., Younkin, St

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 46 KB

english, 2009

30

Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

Wesley Farris, Stefan Mansourian, Malcolm A. Leissring, Elizabeth A. Eckman, Lars Bertram, Christopher B. Eckman, Rudolph E. Tanzi, Dennis J. Selkoe

Journal:

The American Journal of Pathology

Year:

2004

Language:

english

File:

PDF, 370 KB

english, 2004

31

Regional hypomyelination and dysplasia in transgenic mice with astrocyte-directed expression of interferon-γ

Frank M. LaFerla, Michael C. Sugarman, Thomas E. Lane, Malcolm A. Leissring

Journal:

Journal of Molecular Neuroscience

Year:

2000

Language:

english

File:

PDF, 625 KB

english, 2000

32

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Malcolm A Leissring, Wesley Farris, Alice Y Chang, Dominic M Walsh, Xining Wu, Xiaoyan Sun, Matthew P Frosch, Dennis J Selkoe

Journal:

Year:

2003

Language:

english

File:

PDF, 342 KB

english, 2003

33

Alternative Splicing of Human Insulin-Degrading Enzyme Yields a Novel Isoform with a Decreased Ability To Degrade Insulin and Amyloid β-Protein †

Farris, Wesley, Leissring, Malcolm A., Hemming, Matthew L., Chang, Alice Y., Selkoe, Dennis J.

Journal:

Year:

2005

Language:

english

File:

PDF, 1.02 MB

english, 2005

34

P4-189 Identification of a novel translational isoform of insulin-degrading enzyme

Leissring, Malcolm, Farris, Wesley, Wu, Xining, Selkoe, Dennis J.

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

35

Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice

Merino, Beatriz, FernÃ¡ndez-DÃaz, Cristina M., Parrado-FernÃ¡ndez, Cristina, GonzÃ¡lez-Casimiro, Carlos M., Postigo-Casado, Tamara, LobatÃ³n, Carmen D., Leissring, Malcolm A., CÃ³zar-Castellano, Iren

Journal:

Year:

2020

File:

PDF, 5.08 MB

2020

36

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

LEISSRING, Malcolm A., FARRIS, Wesley, WU, Xining, CHRISTODOULOU, Danos C., HAIGIS, Marcia C., GUARENTE, Leonard, SELKOE, Dennis J.

Journal:

Biochemical Journal

Year:

2004

Language:

english

File:

PDF, 390 KB

english, 2004

37

Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin

Vicki Betts, Malcolm A. Leissring, Georgia Dolios, Rong Wang, Dennis J. Selkoe, Dominic M. Walsh

Journal:

Neurobiology of Disease

Year:

2008

Language:

english

File:

PDF, 756 KB

english, 2008

38

P1-206 Capacitative and non-capacitative Ca2+ entry modulate Aβ levels

Yama Akbari, Nabil Dagher, M. Paul Murphy, J. Ashot Kozak, Brian Hitt, Salvatore Oddo, Bert Tseng, Todd E. Golde, Michael Cahalan, Malcolm A. Leissring, Frank M. LaFerla

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 309 KB

english, 2004

39

Herpes Simplex Virus Infections and Alzheimer’s Disease

Malcolm A. Leissring, Michael C. Sugarman, Dr Frank M. LaFerla

Journal:

Year:

1998

Language:

english

File:

PDF, 271 KB

english, 1998

40

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Maianti, Juan Pablo, McFedries, Amanda, Foda, Zachariah H., Kleiner, Ralph E., Du, Xiu Quan, Leissring, Malcolm A., Tang, Wei-Jen, Charron, Maureen J., Seeliger, Markus A., Saghatelian, Alan, Liu, Dav

Journal:

Year:

2014

Language:

english

File:

PDF, 2.20 MB

english, 2014

41

Characterization of Insulin Degrading Enzyme and Other Amyloid-β Degrading Proteases in Human Serum: A Role in Alzheimer's Disease?

Liu, Zhiheng, Zhu, Haihao, Fang, Guang Guang, Walsh, Kathryn, Mwamburi, Mkaya, Wolozin, Benjamin, Abdul-Hay, Samer O., Ikezu, Tsuneya, Leissring, Malcolm A., Qiu, Wei Qiao

Journal:

Journal of Alzheimer's Disease

Year:

2012

Language:

english

File:

PDF, 468 KB

english, 2012

42

P1-391: Monomeric Aβ peptides bearing the Flemish A21G mutation are less readily degraded by neprilysin than wild type Aβ

Vicki Betts, Malcolm A. Leissring, Dennis J. Selkoe, Dominic M. Walsh

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 68 KB

english, 2006

43

Correlation between insulin-degrading enzyme levels and neuropathology in control versus Alzheimer brains with and without cerebral amyloid angiopathy

Anthony DelleDonne, Richard J. Miles, Dennis W. Dickson, Samer O. Abdul-Hay, Nilufer Ertekin-Taner, Malcolm A. Leissring

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

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